Tuesday, February 9, 2010

How to sell yourself

To get ahead in life, you need to be in the business of selling.

The product? You !

When you think about it, if you cannot sell yourself as a person to others, you are going to have a difficult time selling them your ideas, your wishes, your needs, your ambitions, your skills, and your experience.

Despite the necessity of being able to sell yourself to others, for many people like myself it does not come naturally. Introversion, shyness, and lack of self-worth are just a few of the obstacles that can potentially get in the way. To overcome such obstacles, I suggest focusing on the following:

1. Be Sold on Yourself

This is probably also the hardest. Being sold on yourself comes down to this: you must be aware of your own self-worth. This means you believe in yourself, have faith in yourself, and have confidence in yourself.

Here are just 3 ideas that may help:

* Live in such a way that you would want to be friends with yourself
* Find some time to reflect on what you like about yourself. If this seems hard, start with the smallest of attributes.
* Don’t do anything that will give you cause to feel ashamed later.

2. Have a Saleable Package

Let others know about the inner contents of your package.
People judge others based on their appearance.
Therefore, some questions you may consider asking yourself are:
am I looking after my appearance to the best of my ability?
Are my clothes appropriate for the image I wish to project?

3. Be Positive and Enthusiastic

Positivity and enthusiasm can both be developed, but once again it takes work. Here are a few tips to help you:

* Look for the best in people
* Associate with positive people
* Care deeply about something
* See life as an adventure
* Smile

4. Be Real and Authentic

Selling yourself is about letting others know who you are as a person.

Wednesday, February 3, 2010

Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephriti

Original Article

Kidney International (2010) 77, 152–160; doi:10.1038/ki.2009.412; published online 4 November 2009
Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis

Jai Radhakrishnan1,6, Dimitrios-Anestis Moutzouris2,6, Ellen M Ginzler3, Neil Solomons4, Ilias I Siempos5 and Gerald B Appel1

Class V lupus nephritis (LN) occurs in one-fifth of biopsy-proven cases of systemic lupus erythematosus. To study the effectiveness of treatments in this group of patients, we pooled analysis of two large randomized controlled multicenter trials of patients with diverse ethnic and racial background who had pure class V disease. These patients received mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVC) as induction therapy for 24 weeks, with percentage change in proteinuria and serum creatinine as end points. Weighted mean differences, pooled odds ratios, and confidence intervals were calculated by using a random-effects model. A total of 84 patients with class V disease were divided into equal groups, each group had comparable entry variables but one received MMF and one received IVC. Within these groups, 33 patients on MMF and 32 patients on IVC completed 24 weeks of treatment. There were no differences between the groups in mean values for the measured end points. Similarly, no difference was found regarding the number of patients who did not complete the study or who died. In patients with nephrotic syndrome, no difference was noted between those treated with MMF and IVC regarding partial remission or change in urine protein. Hence we found that the response to MMF as induction treatment of patients with class V LN appears to be no different from that to IVC.